Friday, February 1, 2013
Thursday, January 31, 2013
The team from Bristol University has identified how the loss or mutation of a particular molecule can lead to severe obesity and diabetes.
Funded by the British Heart Foundation, the research could lead to treatments for conditions that are linked to obesity and potentially save thousands of lives.
The molecule is critical factor in the brain's regulation of body weight, the Bristol scientists found.
Dr Nina Balthasar, one of the study's lead authors and a researcher in the university's School of Physiology and Pharmacology, said: "Obesity is a major risk factor for cardiovascular disease with recent statistics showing that obese adults are three to four times more likely to develop high blood pressure.
"In order to curb the escalating incidence of obesity and obesity-related diseases, a primary prevention goal must be to understand the physiological processes underlying our vulnerability to weight gain — knowledge that is central to the development of novel, effective therapies."
Dr Shannon Amoils, research advisor at the British Heart Foundation, which part-funded the study, added: "This research increases our understanding of how the nervous system affects our metabolism, and the development of high blood pressure due to obesity.
"With further knowledge of this complex area we hope scientists will be able to find safe and effective ways of treating obesity-related heart and circulatory disorders."
The research has been published in the journal Cell.
The Tapbots App.net post announcing the Netbot sale says it's "[I]n order to spur adoption of App.Net."
Tweetbot, and anyone who uses that app will quickly get used to Netbot. For those who haven't used Tweetbot, just trust that Tapbots is a top-shelf iOS shop and makes apps that feel good and make sense. If you've wanted to try out App.net, this is the app with which to do it.Netbot was born out of Tapbots' beloved Twitter client,
In fact, it was when Tapbots announced their App.net client that much of the tech world started to take App.net seriously. App.net is betting that a paid-for social infrastructure will give rise to a vast field of great apps that have sustainable businesses. That plan needs buy-in from big-name developers.
When Tapbots joined the service, things got interesting. The app caused a huge spike in attention when it first appeared for $4.99. But App.net's adoption hasn't been as swift as the Tapbots duo, programmer Paul Haddad and designer Mark Jardine, had hoped.
But App.net announced this week that paid users will now get 10GB of cloud storage behind their accounts, which app developers can put to any use they can dream up. Not only does that mean more powerful applications can be built, it means that now App.net can build the same kind of freemium revenue model as services like Dropbox and Evernote use. If paying for the service gets you the storage space, App.net can give away the Twitter-like messaging features for free.
Paid-only adoption of App.net hasn't lived up to these bigtime developers' expectations. But if the service becomes free for messaging-only users, that could easily change.